Hot Technologies

In-Situ Preservation Solution for Non-Heart Beating Donated Organs

An in-situ flush solution that activates known biochemical pathways in kidney cells so that a donated organ survives the fatal warm ischemic period.  This could greatly expand the pool of kidneys available for transplant. This invention also has the potential to be applied as a rescue flush to the intestine, liver, heart, and pancreas ex-vivo after non-heart beating donation. 
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A Specific SphK1 Inhibitor, for Treatment of Cancer

A compound that specifically inhibits sphingosine kinase type 1 (SphK1).  SphK1 is critical for cell growth, metastasis, and chemoresistance of cancer cells.  The inhibition of SphK1 by SKI-1 reduces the growth of cancer cells as well as increases sensitivity of these cells to anti-neoplastic drugs. 
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A Genetic Marker to Determine Risk of Premature Birth

A polymorphism in a particular gene confers risk of premature rupture of the fetal membranes.  Screening parental DNA for this polymorphism will identify the patients at risk for preterm delivery.  This would allow physicians to prescribe the appropriate preventive care.    
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Prophylactic and Acute Care for Injury Due to Ischemia and Reperfusion

A treatment has been developed to prevent ischemia-reoxygenation injury in heart attacks and other vascular occlusion events, such as stroke.  Treatment with the drug has been shown to decrease cardiac infarct size by 64% and significantly reduce cell death following ischemia-reoxygenation injury.
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